Audiences--whether 6 or 600--really want three things from you. These apply to meetings, wedding toasts, or keynote speeches:
1. Connection. They want to feel connected to you. They've already endured too many distant, aloof presentations in their lifetimes. Give them you, not a veiled voice in the corner reciting PowerPoint bullets. In fact, to be the "real deal" and "authentic", be even more of you. Wear your enthusiasm for your topic on your sleeve, look into the eyes of participants, and have a bold, honest conversation with them.
2. We all love a bit of entertainment. No one expects you--or even wants you--to be Jimmy Kimmel or Jay Leno. You can do a quick activity that energizes people and gets them thinking more about the topic. It also gives you a break and a chance to relax. Keep it light. Stay serious about your topic but not about yourself. A funny personal story, especially if the joke was on you, can loosen people up and increase the connection. ("Wow, I thought that only happened to me.!) I watched my wife listen to a very well-known speaker/writer from Harvard. My wife has a dual Ph.D. She thought his presentation was so serious and ponderous that he came across as self-important. He lost her, even though his information was accurate.
Note: Did you know that speakers who also sell product actually sell measurably more product when there is humor in their talk?
3. Create meaning. How does what you are saying fit into their business or organizational life? Make the connection for them (don't assume they'll automatically do it themselves). Explain specifically how you or your idea will personally increase their satisfaction or reduce their pain. When you can synthesize the meaning of your topic to that point, you've really got something worth saying.
Connect with the people, connect with a little light humor, and connect the dots.